The China International Barter Trade Center aims to revolutionize the way businesses conduct trade by offering a platform that enables companies to exchange goods and services without the need for conventional currency. This innovative approach opens up new possibilities for businesses to expand their market reach, establish valuable partnerships, and increase efficiency in their trade operations.Ludhiana: Councillor’s flip-flop keeps Congress, AAP on toesFBI Director Wray says he intends to resign before Trump takes office in January
Key investors question PIL that led to HC stay on Religare AGMIn conclusion, while Huawei's smart driving technology is undeniably impressive, car manufacturers are more inclined to partner with Momenta due to factors such as trust, reliability, customization, cost, and agility. By choosing to collaborate with Momenta, car manufacturers are seeking a partner who can provide them with innovative solutions that are not only technologically advanced but also tailored to their specific needs and requirements. As the autonomous driving industry continues to evolve, it will be interesting to see how these partnerships unfold and shape the future of smart mobility.
India’s real estate to remain gung ho on luxury, premium housing in 2025 as affordable takes a backseatUnlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.
For Iowa, it's a chance to tune up going into the bulk of its Big Ten Conference schedule. For New Hampshire, it's an opportunity to collect a nice paycheck and perhaps even pull off a memorable upset. The Hawkeyes and Wildcats will finish their nonconference schedules Monday night when they meet in Iowa City. Iowa (9-3) last played on Dec. 21, erasing an 11-point second-half deficit to outgun Utah 95-88 in Sioux Falls, S.D. Payton Sandfort scored a season-high 24 points and added eight rebounds for the Hawkeyes, while Owen Freeman added 16 despite running into foul trouble. Hawkeyes coach Fran McCaffery praised fifth-year senior Drew Thelwell, Iowa's sixth-leading scorer, who matched his season high with 15 points. "The energy in the building was phenomenal. Drew was right in the middle of that," McCaffery said. "His defense and drawing six fouls, those are stats that are critical to a team's ability to win. Get to the bonus, get to the double bonus. We do that by driving the ball and drawing fouls and that's what we did." Freeman is averaging a team-high 17.1 points and shooting 66.1 percent from the field, while Sandfort adds 16.7 ppg. Iowa has its usual high-powered attack, ranking seventh in Division I in scoring at 87.8 ppg and canning 50.2 percent from the field. The Hawkeyes could add more gaudy offensive numbers against New Hampshire (2-12), which has lost six straight games, including a 90-83 decision on Dec. 22 at Stonehill. The Wildcats have experienced trouble defensively, allowing opponents to sink 45.2 percent of their field goal attempts and score 76.5 ppg. Coming off a successful 2023-24 campaign that saw the Wildcats go 16-15 and win a game in the America East Conference tournament, New Hampshire returned just three players and had to replace AEC Player of the Year Clarence Daniels and his 19.4 ppg. It hasn't gone to the plan of second-year coach Nathan Davis, but he's still hopeful his team can figure things out in conference play. "We've improved across the board as far as our talent level," he said this summer. "I like our pieces." This is the first meeting between the Wildcats and Hawkeyes. --Field Level Media
Zheng Qinyu, a rising star in the world of women's tennis, recently found herself at the center of a storm of controversy as she narrowly missed out on the prestigious WTA Player of the Year award. Instead, the title was snatched away by none other than the formidable Sabalenka, sending shockwaves through the tennis world.
Clevo's next-gen X580 laptop teased: 18-inch display, Arrow Lake-HX CPU, RTX 50 Laptop GPU
Thursday, December 26, 2024 Winter in Boston brings severe snowstorms that can disrupt normal transportation flows. Despite these seasonal challenges, Boston Airport Express is equipped to ensure safe and comfortable journeys for all passengers throughout the colder months. The fleet at Boston Airport Express is winter-ready, boasting vehicles enhanced with state-of-the-art features suitable for snowy conditions. Each vehicle is fitted with heated seats to provide warmth and comfort during travel. Additionally, the cars are equipped with four-wheel drive to enhance traction and stability on icy and snow-covered roads, which is essential for maintaining safety and dependability during winter weather. Boston Airport Express places a high emphasis on passenger safety and satisfaction by continuously investing in advanced vehicle technologies and thorough driver training programs. Travelers can rely on dependable service for timely and effective transportation to and from Boston Logan International Airport and other locations throughout Massachusetts. In times of challenging winter weather, when driving becomes hazardous or other vehicles may fail, the professional drivers and winter-prepared vehicles at Boston Airport Express are ready to assist. Services such as the Boston Town Car Service and long-distance rides from Boston remain operational as long as safety permits. With Boston Airport Express, passengers can navigate the winter season safely and without hassle, ensuring that their travel needs are met with the highest standards of care and professionalism.Firefighters and emergency responders were quick to arrive on the scene, but the intense heat and thick smoke made it difficult for them to contain the blaze. The situation was further exacerbated by the sheer size of the data center, which made it challenging to locate the source of the fire and prevent it from spreading to other areas.FBI Director Wray says he intends to resign before Trump takes office in JanuarySan Jose Sharks winger Luke Kunin is on pace to set a new single-season career high in goals scored. He is in his second season as an alternate captain and plays the type of north-south game coach Ryan Warsofsky appreciates. Those qualities will also likely make Kunin, a pending unrestricted free agent, an attractive trade target among playoff-contending teams early next year. Kunin scored twice and had 16:31 in ice time for the Sharks on Tuesday in their 3-2 loss to the Carolina Hurricanes. Going into Thursday’s date with his hometown St. Louis Blues, Kunin, after 31 games, is now tied for fourth on the team with eight goals, more than halfway past his career high of 15 set during the 2019-2020 season when he played in 63 games with the Minnesota Wild. Now, it’s a matter of whether the Sharks want to try to sign Kunin to a contract extension past this season or trade him for future assets as they did with goalie Mackenzie Blackwood on Monday. Blackwood was traded to the Colorado Avalanche as part of a deal that netted goalie and pending UFA Alexandar Georgiev, 25-year-old forward Nikolai Kovalenko, and two draft picks. After the deal, Sharks general manager Mike Grier said Blackwood likely “played his way out of here” with the season he was having. That means the average annual value of Blackwood’s next contract will probably be significantly higher than the $2.35 million on his current deal. The rebuilding Sharks are only willing to commit so much money to the goaltending position as Yaroslav Askarov’s two-year, $4 million contract kicks in next season. “I hope he gets what he’s looking for,” Grier said of Blackwood. “But I think he kind of played his way out of probably the ballpark figure of what we were looking for, especially with (Askarov) coming up as well.” It’s fair to suggest that Kunin, who turned 27 on Dec. 4, will be looking for a bump from his current AAV of $2.75 million and perhaps some term beyond one or two years on his next contract. He also must decide whether he wants to remain with the rebuilding Sharks, who appear to be at least a couple of years away from being serious playoff contenders. With Kunin a pending restricted free agent in June, he and the Sharks came to terms on a one-year, $2.75 million deal that took him to UFA status. He has 12 points this season and is sixth among Sharks forwards in average time on ice (15:05). Like he will with other pending UFAs before the March 7 trade deadline, Grier must decide whether Kunin fits in with the Sharks in their current state or whether it makes more sense to ship him and collect a future asset. The Sharks’ other pending UFAs are goalies Georgiev and Vitek Vanecek, forwards Mikael Granlund and Nico Sturm, and defensemen Cody Ceci and Jan Rutta. Those players, too, must decide whether to stay or move on. Regardless, Kunin, who sustained a torn right ACL in Dec. 2022 in his first season with the Sharks, appears to be helping his value with his improved skating and production. Kunin had 11 goals and 18 points in 77 games last season. “I think he’s been solid,” Warsofsky said after Tuesday’s loss. “We’re seeing a guy that’s skating more, first and foremost, gets to the inside of the ice, kind of the heart and soul of our team, really. He gives you everything he’s got. To get rewarded with two goals is nice.” MUKHAMADULLIN TO PLAY: Warsofsky said Wednesday in St. Louis that defenseman Shakir Mukhamadullin would play against the Blues as the Sharks play the final game of a six-game road trip. After Tuesday’s game, the Sharks announced that Mukhamadullin had been recalled from the AHL and that defenseman Jack Thompson and forward Ethan Cardwell had been loaned back to the Barracuda. Mukhamadullin had six assists in 14 games with the Barracuda this season after the Sharks assigned him to the AHL on Oct. 22. His most recent game was on Dec. 8, when he had two assists in the Barracuda’s 2-1 win over Coachella Valley. Mukhamadullin, acquired from New Jersey in Feb. 2023 as part of the blockbuster trade that sent Timo Meier to the Devils, played in three games with the Sharks last season – all in January – and averaged over 21 minutes of ice time per game and had one assist. The Sharks have lost three straight and are 2-3-0 on the trip that began close to two weeks ago with wins over the Seattle Kraken and Washington Capitals. PULLI OUT: The Sharks on Wednesday placed defenseman Valtteri Pulli on unconditional waivers for the purpose of terminating his NHL contract. “Valtteri requested to play in Europe and we mutually agreed to terminate his contract,” Sharks assistant general manager Joe Will said in a statement. “We want to thank Valtteri for his contributions to the organization and wish him all the best.” Pulli, 23, was signed to a two-year, two-way contract by the Sharks in May 2023 after he played three seasons with TPS Turku of the Finnish League. The 6-foot-5, 215-pound Pulli never played for the Sharks, but had 10 points in 59 games for the San Jose Barracuda of the AHL last season. Pulli was healthy again this season but only dressed for two Barracuda games, both in October. He had one assist in an Oct. 19 game against the Iowa Wild.
So mark your calendars and get ready for the release of the Original HarmonyOS 2024 Annual Pioneer List. With an upgraded experience, plenty of surprises, and a wealth of talented individuals to celebrate, there has never been a better time to be a part of the Original HarmonyOS community. Don't miss out on all the excitement – join us as we celebrate the pioneers of tomorrow and the incredible innovations they bring to the world of technology.
HarborOne Bank’s Inez Friedman-Boyce named Women We Admire’s Top 50 Women Leaders in BankingINDIANAPOLIS — It was just a 10-yard completion, easy to overlook in the wake of a record-setting rushing day and easy to dismiss as one of just 11 pass attempts throughout the Indianapolis Colts’ 38-30 victory Sunday against the Tennessee Titans. But Anthony Richardson’s third-and-8 pass to wide receiver Michael Pittman Jr. just after the two-minute warning in the fourth quarter was pivotal to holding off the visitors’ late rally. If the Colts were forced to punt in that situation, a defense that had allowed touchdowns on three consecutive drives — of 70, 55 and 71 yards — would be back on the field with tremendous pressure to prevent the game going to overtime. Richardson was cold and out of rhythm. He’d been sacked on his most recent pass attempt — on third-and-9 with 6:51 remaining — and he hadn’t gotten a pass off since throwing an incompletion intended for wide receiver Josh Downs at the 11:20 mark. With the dual-threat quarterback and running back Jonathan Taylor combining for 270 of Indianapolis’ single-game franchise-record 335 rushing yards, Richardson had not completed a pass since the 8:33 mark of the third quarter, and he was just 1-for-2 in the second half. Still, he was calm and composed on the crucial third down — hitting Pittman on a simple out pattern to move the chains and keep the clock moving. When the Colts finally did punt the ball back to Tennessee, there were only three seconds remaining for the Titans to work with, It was a forgettable play in the grand scheme of the game, but it was also the most recent evidence of the 22-year-old quarterback’s ability to raise his level of play in the clutch. He’s 3-2 as a starter since taking the role back from veteran Joe Flacco, and the other two victories featured game-winning touchdown drives in the fourth quarter. “I think that’s a special trait — obviously as a young player — that he doesn’t flinch in those times, to lead those comebacks,” Colts head coach Shane Steichen said. “Obviously, the (New York) Jets, the New England (Patriots) game, I mean, those are big-time drives to go win games. “You want that out of young players, especially (when) you see the veteran guys do it around the league all the time, but to do it as a young player speaks volumes of the person that he is.” Despite Richardson’s up-and-down season, Indianapolis has maintained steadfast belief in his potential. Even when he was benched for Flacco, the organization repeatedly stated it was not giving up on the quarterback as its future leader. There’s still plenty of work to be done. Richardon has completed just 47.7% of his passes, and he’s thrown 12 interceptions in 11 starts. His rushing ability again was evident Sunday, and he’s set franchise single-season records for a quarterback with 499 rushing yards and six rushing touchdowns. And he has proven his big-play ability with a league-leading 14.4 yards per completion. The Colts still believe improved consistency will come with increased reps, and they hold out hope the fourth overall pick in the 2023 NFL Draft can still become the long-term answer at the game’s most important position. For now, Richardson’s late-game heroics offer the most compelling argument in his favor. “I think it’s just me just playing all the way until the clock hits zero,” Richardson said of his mindset. “I never think about fourth quarter moments or anything like that. I just try to play until the game’s over. And it just happens sometimes that most of it happens in the fourth quarter. So I just try to play through the whistle and just play through the whole game.” After rushing for 218 yards and three touchdowns against the Titans – both the second-highest single-game totals of his career – Taylor has been named the AFC Offensive Player of the Week. It was a major bounce-back performance after Taylor’s unforced fumble just short of the goal line cost the Colts dearly in a pivotal loss against the Denver Broncos a week prior. “It’s always exciting to see that dude just do what he does,” Richardson said. “It’s fascinating, honestly, just to see him hit a gap and just take it to the house. It’s just amazing, especially thinking about what happened in the Denver game. It honestly like wiped my mind. I wasn’t even thinking about it until people were talking about him coming back and having the game he did. “It’s like ‘OK, that’s the type of player he is, the type of person he is.’ He always wants to do better for the team and for himself. And just to see him do that and get what he did on Sunday is just a blessing.” The Colts officially signed right guard Mark Glowinski to the 53-man roster Tuesday after he’d been called up for game day in each of the past three weeks. Guard Antonio Mafi was re-signed to the practice squad after being released from the 53-man roster Monday.
49ers’ Shanahan expects Jake Moody to be his kicker into the future
